Synthesis of enantiopure α,α-disubstituted amino acids from the asymmetric Strecker reaction products of aldehydes

[GRAPHICS] Treatment of the enolates of 4 generated from the asymmetric Strecker reaction products with alkyl halides or aldehydes provided the corresponding functionalized products with high diastereoselectivity. Deprotection of these products afforded the corresponding enantiopure alpha,alpha-dialkyl amino acids.