Journal
CANCER LETTERS
Volume 156, Issue 2, Pages 125-132Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(00)00451-1
Keywords
neurosteroids; steroidogenesis; glioma; human; tumor biopsy
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Funding
- NCI NIH HHS [CA-80763] Funding Source: Medline
- NIEHS NIH HHS [ES-07747] Funding Source: Medline
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We examined the localization and function of the peripheral-type benzodiazepine receptor (PBR), a protein highly expressed in steroidogenic tissues and aggressive tumor cells, in cell lines derived from glioblastoma multiforme tumors. In MGM-1 cells, PER is located in the nucleus, and cells proliferate in response to PER ligands but do not synthesize steroids de novo. In MGM-3 cells, PER is located in mitochondria and the cells synthesize steroids, but do not proliferate in response to PER ligands. In glioblastoma biopsies, PER is expressed in the nuclei of cells, while it is found in the cytosol of astrocytomas, and is absent from meningioma and medulloblastoma tumor biopsies. These data suggest that the subcellular localization of PER defines its function. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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