Journal
NUCLEIC ACIDS RESEARCH
Volume 28, Issue 16, Pages 3011-3016Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/28.16.3011
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Funding
- NCRR NIH HHS [RR 14549-01] Funding Source: Medline
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Wide-scale DNA testing requires the development of small, fast and easy-to-use devices, This article describes the preparation, operation and applications of biosensors and gene chips, which provide fast, sensitive and selective detection of DNA hybridization. Various new strategies for DNA biosensors and gene chips are examined, along with recent trends and future directions. The integration of hybridization detection schemes with the sample preparation process in a 'Lab-on-a-Chip' format is also covered. While the use of DNA biosensors and gene chips is at an early stage, such devices are expected to have an enormous effect on future DNA diagnostics.
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