Journal
NATURE
Volume 406, Issue 6797, Pages 782-787Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35021228
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The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
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