Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 275, Issue 1, Pages 203-208Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.3232
Keywords
transcription; repression; thyroid; TTF-1; TTF-2; Pax8
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Funding
- Telethon [D.067] Funding Source: Medline
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The thyroid transcription factor TTF-S is a forkhead-containing protein involved in thyroid-specific gene expression and necessary for thyroid morphogenesis. In this paper, we demonstrate that TTF-2 is able to inhibit the activity of the thyroid-specific transcription factors TTF-1 and Pax-8 only on certain promoters. We identified the minimal protein domain responsible for repressor activity, which behaves as an independent functional domain, and me show that repression by TTF-g is DNA-binding independent. We suggest that TTF-2 is able to interfere with a specific cofactor required for TTF-1 and Pax-8 activity. (C) 2000 Academic Press.
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