Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 275, Issue 1, Pages 20-25Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.3270
Keywords
Spirulina platensis; C-phycocyanin; reduced phycocyanin; peroxyl radical scavenger; hepatotoxicity
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C-Phycocyanin (from Spirulina platensis) effectively inhibited CCl4-induced lipid peroxidation in rat liver in vivo. Both native and reduced phycocyanin significantly inhibited peroxyl radical-induced lipid peroxidation in rat liver microsomes and the inhibition was concentration dependent with an IC50 of 11.35 and 12.7 mu M, respectively. The radical scavenging property of phycocyanin was established by studying its reactivity with peroxyl and hydroxyl radicals and also by competition kinetics of crocin bleaching. These studies have demonstrated that phycocyanin is a potent peroxyl radical scavenger with an IC50 of 5.0 mu M and the rate constant ratios obtained for phycocyanin and uric acid (a known peroxyl radical scavenger) were 1.54 and 3.5, respectively. These studies clearly suggest that the covalently linked chromophore, phycocyanobilin, is involved in the antioxidant and radical scavenging activity of phycocyanin. (C) 2000 Academic Press.
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