Journal
SCIENCE
Volume 289, Issue 5482, Pages 1185-1187Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5482.1185
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In determining the mechanism of neutrophil elastase (NE)-mediated killing of Escherichia coli, we found that NE degraded outer membrane protein A (OmpA), Localized on the surface of Cram-negative bacteria. NE killed wild-type, but not OmpA-deficient, E, coli. Also, whereas NE-deficient mice had impaired survival in response to E, coli sepsis, as compared to wild-type mice, the presence or absence of NE had no influence on survival in response to sepsis that had been induced with OmpA-deficient E. coli. These findings define a mechanism of nonoxidative bacterial killing by NE and point to OmpA as a bacterial target in host defense.
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