Journal
NEUROREPORT
Volume 11, Issue 12, Pages 2811-2816Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200008210-00040
Keywords
Boc-Asp-FMK; caspase; hippocampus; long-term spatial memory; Morris water maze
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Funding
- NIMH NIH HHS [MH49662] Funding Source: Medline
- NINDS NIH HHS [NS35457] Funding Source: Medline
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Activation of intracellular second messenger cascades has been linked to learning and memory in various organisms. Identification of down-stream targets of these second messengers that play a role in learning and memory is an active area of research. Recently, it has been reported that increases in intracellular calcium can activate a cysteine-dependent aspartate-directed protease (caspase) cascade in mice. Using an antibody that selectively recognizes activated caspase-3, we detected the presence of this enzyme in hippocampal neurons. Inhibition of caspase activity in the hippocampus blocked longterm, but not short-term, spatial memory. These results suggest that a caspase-mediated cellular event(s) in hippocampal neurons is critical for long-term spatial memory storage. (C) 2000 Lippincott Williams & Wilkins.
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