Journal
FEBS LETTERS
Volume 480, Issue 1, Pages 42-48Publisher
WILEY
DOI: 10.1016/S0014-5793(00)01776-2
Keywords
genomics; bioinformatics; algorithm; molecular biology database; genomic context; systems modelling; knowledge representation
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Computational genomics is a subfield of computational biology that deals with the analysis of entire genome sequences. Transcending the boundaries of classical sequence analysis, computational genomics exploits the inherent properties of entire genomes by modelling them as systems. We review recent developments in the field, discuss in some detail a number of novel approaches that take into account the genomic context and argue that progress will be made by novel knowledge representation and simulation technologies. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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