Journal
REGULATORY PEPTIDES
Volume 92, Issue 1-3, Pages 37-43Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-0115(00)00147-6
Keywords
transporter; satiety; fasting; obesity
Categories
Funding
- NIDDK NIH HHS [DK54880] Funding Source: Medline
Ask authors/readers for more resources
Regulation of the transport of leptin across the blood-brain barrier (BBB) may be crucial for its effects on food ingestion and obesity and may be responsible for 'leptin resistance'. This review summarizes current studies of leptin indicating a dynamic role of the BBB. It includes evidence for its susceptibility to change by physiological stimuli such as starvation, refeeding, and time of day. Although the short form of the leptin receptor is involved in leptin transport, it appears that other mechanisms of entry also exist. Regardless, the BBB is intimately involved with the regulation of the actions of leptin. (C) 2000 Published by Elsevier Science B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available