Journal
CANCER LETTERS
Volume 157, Issue 1, Pages 77-85Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(00)00478-X
Keywords
Epstein-Barr virus; superoxide anion; cyclooxygenase-2; inducible nitric oxide synthase; chemoprevention
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A total of 23 ferulic acid (FA) derivatives were synthesized, and investigated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus (EBV) activation and superoxide (O-2(-)) generation. Most of the derivatives showed significant EBV activation suppression or cytotoxicity at a concentration of 100 muM, with FA15 as the most potent suppressor. In both assays, FA6-FA17, bearing straight- or branched-alkyl side chains, exhibited marked suppression of O-2(-) generation, with both FA16 and FA17 being highly active, while FA itself was virtually inactive. The activity differences seen between FA16/FA17 and FA are attributable, at least in part, to their cellular incorporating efficiencies. Further, both FA15 and FA21 attenuated the expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins, while FA did not. Our results suggest that these novel FA derivatives are effective chemopreventive agents. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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