Journal
CANCER LETTERS
Volume 157, Issue 1, Pages 87-92Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(00)00479-1
Keywords
cancer chemopreventive activity; 8-acetylharpagide; Ajuga decumbens; nitric oxide donor; (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide; hepatic tumor inhibitor
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In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Labiatae plants were screened. Consequently, the iridoid glycoside derivative, 8-acetylharpagide (8-AcHarp), was obtained from the flowering whole plant of Ajuda decumbens as an active constituent. This glycoside exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mo use skin tumors induced by nitric oxide (NO) donor, (+/-)-(E)-methyl-2-[(E)hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide (NOR 1) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, 8-AcHarp exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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