Journal
NATURE CELL BIOLOGY
Volume 2, Issue 9, Pages 645-652Publisher
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/35023595
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Mammalian cells respond to stress by accumulating or activating a set of highly conserved proteins known as heat-shock proteins (HSPs), Several of these proteins interfere negatively with apoptosis, We show that the small HSP known as Hsp27 inhibits cytochrome-c-mediated activation of caspases in the cytosol, Hsp27 does not interfere with granzyme-B-induced activation of caspases, nor with apoptosis-inducing factor-mediated, caspase-independent, nuclear changes. Hsp27 binds to cytochrome c released from the mitochondria to the cytosol and prevents cytochrome-c-mediated interaction of Apaf-1 with procaspase-9, Thus, Hsp27 interferes specifically with the mitochondrial pathway of caspase-dependent cell death.
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