Journal
TRENDS IN GENETICS
Volume 16, Issue 9, Pages 383-388Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(00)02075-8
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Funding
- NHLBI NIH HHS [HL49579, HL63206] Funding Source: Medline
- NIDDK NIH HHS [DK55383] Funding Source: Medline
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The genes that drive heart-cell differentiation in vertebrates and Drosophila are similar, even though the Drosophila 'heart' is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily 'new' organotypic components.
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