Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 109, Issue 1, Pages 16-22Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(00)00297-6
Keywords
glucocorticoid; NF-kappa B; repression; inflammation; transcription factor
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Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription Factors, such us nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappa B-alpha (I kappa B-alpha) upregulatory model, the protein-protein interaction model and the competition model. (C) 2000 Elsevier Science BN. All rights reserved.
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