Journal
SCIENCE
Volume 289, Issue 5484, Pages 1501-1504Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5484.1501
Keywords
-
Categories
Ask authors/readers for more resources
The study of the biology of osteoblasts, or bone-forming cells, illustrates how mammalian genetics has profoundly modified our understanding of cell differentiation and physiologic processes. Indeed, genetic-based studies over the past 5 years have revealed how osteoblast differentiation is controlled through growth and transcription factors. Likewise, the recent identification, using mutant mouse models, of a central component in the regulation of bone formation expands our understanding of the control of bone remodeling. This regulatory Loop, which involves the hormone Leptin, may help to explain the protective effect of obesity on bone mass in humans. In addition, it provides a novel physiologic concept that may shed Light on the etiology of osteoporosis and help to identify new therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available