Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 72, Issue 1-2, Pages 299-304Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0378-8741(00)00235-X
Keywords
Nigella sativa; gastric secretion; ethanol ulcer
Ask authors/readers for more resources
The present work was done to investigate the possible effects of Nigella sativa oil (NSO) on gastric secretion and ethanol-induced ulcer in rats. Thirty two adult male rats were used in this study (four groups) and several parameters were determined to assess any degree of protection. It was found that the administration of NSO in rats produced a significant increase in mucin content and glutathione level and a significant decrease in mucosal histamine content. Ethanol administration produced a 100% ulcer induction with an ulcer score of 12.62 +/- 1.35 (mean +/- S.E., n = 8). It caused a significant reduction in free acidity and glutathione level while it produced a significant increase in mucosal histamine content. When animals were pretreated with NSO before induction of ulcer, there was a significant increase in glutathione level, mucin content and free acidity and a significant decrease in gastric mucosal histamine content with a protection ratio of 53.56% as compared to the ethanol group. In can be concluded that NSO imparted a protective action against ethanol induced ulcer in rats. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available