Journal
INFECTION AND IMMUNITY
Volume 68, Issue 9, Pages 5443-5446Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.9.5443-5446.2000
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- Wellcome Trust Funding Source: Medline
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Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P > 0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P < 0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
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