4.4 Article

Polystyrylboronic acid as a reusable polymeric support for oligosaccharide synthesis

Journal

TETRAHEDRON LETTERS
Volume 41, Issue 36, Pages 6965-6968

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01184-9

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Polystyrylboronic acid is an attractive polymeric support for oligosaccharide synthesis that can easily be prepared in high loading capacity and re-used after a synthetic sequence. Saccharides were loaded by heating in pyridine and released by treatment with a mixture of acetone and water. NIS/TMSOTf mediated glycosidations of thioglycosides gave a quantitative formation of disaccharides. (C) 2000 Published by Elsevier Science Ltd.

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