Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 192, Issue 5, Pages 671-680Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.192.5.671
Keywords
cytokine; B lymphocyte; growth factor; lymphocyte differentiation; DNA sequence
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Funding
- NIAID NIH HHS [R01 AI024137, AI44160, AI24137] Funding Source: Medline
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Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated from a thymic stromal cell line. This factor, termed thymic stromal lymphopoietin (TSLP), isa protein of 140 amino acids. The gene encoding TSLP was mapped to murine chromosome 18. Purified recombinant TSLP supported the growth of pre-B cell colonies in vitro, but had no myelopoietic activity. TSLP had comitogenic activity for fetal thymocytes, but was not as potent as interleukin 7 in lobe submersion cultures. Injection of TSLP into neonatal mice induced the expansion of B220(+)BP-1(+) pre-B cells.
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