Polymer-supported reagents for multi-step organic synthesis: Application to the synthesis of sildenafil

Sildenafil 1 (Viagra(TM)), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods. (C) 2000 Elsevier Science Ltd. All rights reserved.