Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Volume 1493, Issue 1-2, Pages 211-214Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4781(00)00148-2
Keywords
genome structure; sugar regulation; zinc-finger; aflatoxin; hexose transport; glucosidase; NADH oxidase
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At one end of the 70 kb aflatoxin biosynthetic pathway gene cluster in Aspergillus parasitictus and Aspergillus flavus reported earlier, we have cloned a group of four genes that constitute a well-defined gene cluster related to sugar utilization in A. parasiticus: (1) sugR, (2) hxtA, (3) glcA and (4) nadA. No similar well-defined sugar gene cluster has been reported so far in any other related Aspergillus species such as A. flavus, A. nidulcans, A. sojae, A. niger, A. oryzae and A. fumigatus. The expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium. This is significant since a close linkage between the two gene clusters could potentially explain the induction of aflatoxin biosynthesis by simple sugars such as glucose or sucrose. (C) 2000 Published by Elsevier Science B.V.
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