Journal
SCIENCE
Volume 289, Issue 5485, Pages 1754-1757Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5485.1754
Keywords
-
Categories
Ask authors/readers for more resources
During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells produce various kinds of specified precursors that divide a limited number of times before they terminally differentiate into either neurons OF glial cells. We show here that certain extracellular signals can induce oligodendrocyte precursor cells to revert to multipotential neural stem cells, which can self-renew and give rise to neurons and astrocytes, as well as to oligodendrocytes, Thus, these precursor cells have greater developmental potential than previously thought.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available