Journal
NEUROREPORT
Volume 11, Issue 13, Pages 2925-2929Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200009110-00019
Keywords
microdialysis; prefrontal cortex; rTMS; serotonin
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Repetitive transcranial magnetic stimulation (rTMS) is a novel procedure which has proven effective in the treatment of major depression. We administered rTMS chronically to rats in order to determine whether this procedure affected serotonergic neurotransmission in the prefrontal cortex. Basal 5-HT levels, and the effects of challenges with the 5-HTIA receptor agonist 8-OH-DPAT and the 5-HTIB antagonist GR 127935 on 5-HT levels were determined using in vivo microdialysis. Rats which had undergone chronic rTMS showed reduced responses to both challenges, indicating subsensitivity of both the presynaptic 5-HTIA autoreceptors situated somatodendritically in the raphe nuclei and the 5-HTIB autoreceptors situated on nerve terminals. Since such subsensitivity has been demonstrated after other antidepressant treatments, our results indicate that these treatments and rTMS may have a common mechanism of action. NeuroReport 11:2925-2929 (C) 2000 Lippincott Williams & Wilkins.
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