Journal
NEUROREPORT
Volume 11, Issue 13, Pages 3001-3005Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200009110-00035
Keywords
bone marrow stromal cell; rat; spinal cord injury; transplantation
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Funding
- NINDS NIH HHS [R01 NS35504, P01 NS23393] Funding Source: Medline
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We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the spinal cord after a contusion injury promotes functional outcome. Rats (n=31) were subjected to a weight driven implant injury. MSCs or phosphate buffered saline was injected into the spinal cord 1 week after injury. Sections of tissue were analyzed by double-labeled immunohistochemistry for MSC identification. Functional outcome measurements using the Basso-Beattie-Bresnehan score were performed weekly to 5 weeks post-injury. The data indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals. Scattered cells derived from MSCs expressed neural protein markers. These data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury. NeuroReport 11:3001-3005 (C) 2000 Lippincott Williams & Wilkins.
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