Journal
NEUROSCIENCE LETTERS
Volume 291, Issue 2, Pages 73-76Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01373-2
Keywords
neurotoxicity; nociception; peripheral neuropathy; sensory function; cisplatin
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This work describes the behavioural responses of Sprague-Dawley rats to mechanical or thermal stimuli during and after administration of ten intraperitoneal injections of, alternatively, 1 and 2 mg/kg cisplatin every three days (cumulative dose: 15 mg/kg). Nociceptive signs including mechanical allodynia and hyperalgesia appeared after 3 and 6 cisplatin injections, respectively, and were maintained until 15 days after the last injection. The conservation of a good clinical status and fast appearance of symptoms are favourable criteria for using this animal model to understand the pathophysiological mechanisms implicated in the cisplatin-induced sensory peripheral neuropathy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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