Journal
JOURNAL OF IMMUNOLOGY
Volume 165, Issue 6, Pages 2982-2986Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.6.2982
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- NHLBI NIH HHS [HL56385] Funding Source: Medline
- NIAID NIH HHS [AI30663] Funding Source: Medline
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The cytokines IL-4, IL-13, and IL-5 are markers for the Th2 subset of effector T cells and are often expressed together. These cytokine genes are organized within 140 kb of orthologous DNA in both mouse and human. Using IL-1-expressing CD4(+) T cell clones derived from F-1 mice, we identified allelic polymorphisms for each of these cytokines and assessed the parental identity of the cytokine mRNAs, Both monoallelic and biallelic expression occurred for each gene and for an additional gene, IL-3, that lies with GM-CSF over 450 kh telomeric on the same chromosome. When coexpressed in T cell clones, IL-4 was expressed from the same allele as IL-13 or IL-5 in 81% of instances. In contrast, there was only 52% concordance of these three cytokines at the allelic level among clones that expressed IL-3, Independent expression of the cytokine alleles occurs commonly in T cells, but the clustered locus encompassing IL-4, IL-13, and IL-5 is subject to coordinate regulation.
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