Journal
LANCET
Volume 356, Issue 9234, Pages 999-1000Publisher
LANCET LTD
DOI: 10.1016/S0140-6736(00)02719-7
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We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) in human beings are caused by the same infectious agent, and the sheep-BSE experimental model has a similar pathogenesis to that of human vCJD. Although Uh blood transfusions ale leucodepleted-a possible protective measure against any risk from blood transmission-this report suggests that blood donated by symptom-free vCJD-infected human beings may represent a risk of spread of vCJD infection among the human population of the UK.
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