Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 43, Issue 19, Pages 3577-3580Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm0000315
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The primary hydroxyl group in hydroxymethylacylfulvene, a potent antitumor drug, is readily replaced by thiols including cysteine, N-acetylcysteine, homocysteine, and glutathione. Best yields are obtained when reaction is carried out in the presence of dilute sulfuric acid. A variety of sulfur-containing analogues have been prepared, and their toxicity to tumor cells was examined.
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