Journal
FEBS LETTERS
Volume 481, Issue 3, Pages 209-212Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02006-8
Keywords
AMP kinase; phosphoenolpyruvate carboxykinase; glucose; AICAR; hepatocyte
Ask authors/readers for more resources
The effect of AMP-activated protein kinase (AMPK) in the regulation of the phosphoenolpyruvate carboxykinase (PEPCK) gene expression was studied in isolated rat hepatocytes, Activation of AMPK by AICAR counteracted the inhibitory effect of glucose on the PEPCK gene expression, both at the mRNA and the transcriptional levels. It is proposed that a target for AMPK is involved in the inhibitory effect of glucose on PEPCK gene transcription. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available