Journal
CARBOHYDRATE RESEARCH
Volume 328, Issue 3, Pages 293-299Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(00)00113-0
Keywords
enzyme catalysis; transglycosylation; alpha-L-fucosidase; Penicillium multicolor; alpha-L-Fucp-(1 -> 3) linkage
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The alpha-L-Fucp-(1 --> 3)-D-GlcpNAc disaccharide structure is a vital core unit of the oligosaccharide components of glycoconjugates isolated from human milk and blood group substances, alpha-L-Fucosidase from Penicillium multicolor catalyses the transfer of L-fucose from donor structures such as alpha-L-FucpOpNP and alpha-L-FucpF to various GlcpNAc derivatives and Glcp, forming alpha-(1 --> 3) linkages. The synthesis of several biologically relevant disaccharides including alpha-L-Fucp-(1 --> 3)-alpha-D-GlcpNAcOMe, alpha-L-Fucp-(1 --> 3)-alpha-D-GlcpNAcOAll, alpha-L-Fucp-(1 --> 3)-beta-D-GlcpNAcOAll, alpha-L-Fucp-(1 --> 3)-D-GlcpNAc and alpha-L-Fucp-(1 --> 3)-D-Glcp has been achieved in up to 34% yields by application of this enzyme. (C) 2000 Elsevier Science Ltd. All rights reserved.
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