4.5 Article

A convenient synthesis of glycosyl chlorides from sugar hemiacetals using triphosgene as the chlorine source

Journal

CARBOHYDRATE RESEARCH
Volume 328, Issue 3, Pages 431-434

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(00)00115-4

Keywords

glycosyl chloride; sugar hemiacetal; triphosgene

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Treating partially protected sugar hemiacetals with triphosgene in THF results in the formation of glycosyl chlorides. The method is compatible with acid-sensitive isopropylidene protecting groups in the hemiacetal substrates. (C) 2000 Elsevier Science Ltd. All rights reserved.

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