Journal
BRAIN RESEARCH
Volume 878, Issue 1-2, Pages 194-198Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02741-4
Keywords
beta-amyloid protein; apoptosis; exendin (5-39); glucagon-like peptide-1; hippocampus; memory
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We examined the effects of continuous infusion of exendin (5-39), an antagonist of glucagon-like peptide-1 (GLP-1) receptors, into the rat brain using a mini-osmotic pump on beta-amyloid protein-induced amnesia and apoptosis. Co-infusion of exendin (5-39) with beta-amyloid protein (1-40) prevented the memory impairment and DNA fragmentation in the hippocampal CA1 region observed with infusion of beta-amyloid protein alone. These results indicated a functional role of endogenous GLP-1 in beta-amyloid protein-induced neurotoxicity. (C) 2000 Elsevier Science B.V. All rights reserved.
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