Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 405, Issue 1-3, Pages 139-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00547-1
Keywords
stress; glucocorticoid; cytokine; ageing; Alzheimer's disease
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A potential injury to the hippocampus has been postulated by the glucocorticoid cascade hypothesis as deriving from the Life-long exposure to the stress glucocorticoid hormone. This hypothesis has been extensively resorted to in the search of a physio-pathological basis of the cognitive and behavioural impairments of old age, as well as for assigning to the hormone a not-irrelevant pathogenic role in brain degenerative diseases. Here I discuss the experimental evidences that have credited to stress a killing-licence, and pose, on the contrary, that the modest degrees of hypercortisolemia present in the above conditions could be interpreted as a beneficial occurrence. (C) 2000 Elsevier Science B.V. All rights reserved.
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