Journal
BIOLOGICAL CHEMISTRY
Volume 395, Issue 11, Pages 1341-1352Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2014-0178
Keywords
chaperones; connectin; heat shock proteins
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Funding
- German Research Foundation [KR 3409/5-1]
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The giant sarcomeric protein titin has multiple important functions in striated muscle cells. Due to its gigantic size, its central position in the sarcomere and its elastic I-band domains, titin is a scaffold protein that is important for sarcomere assembly, and serves as a molecular spring that defines myofilament distensibility. This review focuses on the emerging role of titin in mechanosensing and hypertrophic signaling, and further highlights recent evidence that links titin to sarcomeric protein turnover.
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