Journal
BIOLOGICAL CHEMISTRY
Volume 395, Issue 11, Pages 1307-1314Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2014-0180
Keywords
aging; biological age; chromatin; DNA-methylation; histone; predictor
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Funding
- Stem Cell Network North Rhine Westphalia
- Else-Kroner Fresenius Stiftung
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Aging is associated with the deterioration of biological functions, which is either caused by accumulation of random defects or mediated by a controlled process. This article provides an overview of age-associated epigenetic alterations in the histone code, DNA-methylation (DNAm) pattern, and chromatin structure. In particular, age-related DNAm changes are highly reproducible at specific sites in the genome. The DNAm level at few CpGs facilitates estimation of chronological age and there is evidence that such predictions are indicative for biological age. Overall, aging appears to be associated with a tightly regulated epigenetic process, but the underlying mechanism remains to be elucidated.
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