Journal
BIOLOGICAL CHEMISTRY
Volume 394, Issue 3, Pages 335-345Publisher
WALTER DE GRUYTER & CO
DOI: 10.1515/hsz-2012-0290
Keywords
glycosylphosphatidylinositol anchor; G protein-coupled receptor; inducible nitric oxide synthase; inflammation; peroxynitrite; protein-protein interaction
Categories
Funding
- National Institutes of Health [DK41431, HL60678]
- American Heart Association
Ask authors/readers for more resources
The G protein-coupled receptors (GPCRs) are the largest class of membrane proteins that play key roles in transducing extracellular signals to intracellular proteins to generate cellular responses. The kinin GPCRs, named B1 (B1R) and B2 (B2R), are responsible for mediating the biological responses to kinin peptides released from the precursor kininogens. Bradykinin (BK) or kallidin (KD) are agonists for B2Rs, whereas their carboxypeptidase (CP)-generated metabolites, des-Arg(9)-BK or des-Arg(10)-KD, are specific agonists for B1Rs. Here, we review the evidence for a critical role of membrane-bound CPM in facilitating B1R signaling by its ability to directly activate the receptor via conformational crosstalk as well as generate its specific agonist. In endothelial cells, the CPM/B1R interaction facilitates B1R-dependent high-output nitric oxide under inflammatory conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available