Journal
BIOLOGICAL CHEMISTRY
Volume 394, Issue 7, Pages 831-843Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2013-0128
Keywords
apoptin; apoptosis; caspase; prostate cancer; quinazolines; survivin
Categories
Funding
- National Institutes of Health [R01-GRANT00491815]
- National Center for Research Resources
- National Center for Advancing Translational Sciences [UL1RR033173]
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The identification of the fundamental role of apoptosis in the growth balance and normal homeostasis against cell proliferation led to the recognition of its loss contributing to tumorigenesis. The mechanistic significance of reinstating apoptosis signaling towards selective targeting of malignant cells heavily exploits the caspase family of death-inducing molecules as a powerful therapeutic platform for the development of potent anticancer strategies. Some apoptosis inhibitors induce caspase expression and activity in preclinical models and clinical trials by targeting both the intrinsic and extrinsic apoptotic pathways and restoring the apoptotic capacity in human tumors. Furthermore, up-regulation of caspases emerges as a sensitizing mechanism for tumors exhibiting therapeutic resistance to radiation and adjuvant chemotherapy. This review provides a comprehensive discussion of the functional involvement of caspases in apoptosis control and the current understanding of reactivating caspase-mediated apoptosis signaling towards effective therapeutic modalities in cancer treatment.
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