Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 4, Issue 5, Pages 524-530Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(00)00126-5
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For many biological molecules, force is an important functional and structural parameter. With the rapidly growing knowledge about the relation between structure, function, and force, single-molecule force spectroscopy has become a versatile analytical tool for the structural and functional investigation of single bio-molecules in their native environments. Within the past year, detailed insights into binding potentials of receptor ligand pairs, protein folding pathways, molecular motors, DNA mechanics and the functioning of DNA-binding agents (such as proteins and drugs), as well as the function of molecular motors, have been obtained.
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