Journal
BIOLOGICAL CHEMISTRY
Volume 394, Issue 5, Pages 631-639Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2012-0317
Keywords
coenzyme Q; cytochrome c; respiratory chain; substrate channeling
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Substantial evidence exists that the mitochondrial respiratory chain is organized in supramolecular units called supercomplexes or respirasomes. While the structural evidence of the supercomplexes is overwhelming, fewer studies have focused on their functional relevance. Although the presence of coenzyme Q channeling between complexes I and III has been ascertained, no such clear demonstration has been carried out for cytochrome c between complexes III and IV, at least in mammalian mitochondria. This review also discusses the implications concerning the number of respiratory complexes organized in supercomplexes and the possibility that they represent associations in dynamic equilibrium with the individual complexes.
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