4.3 Article

The GlycanBuilder and GlycoWorkbench glycoinformatics tools: updates and new developments

Journal

BIOLOGICAL CHEMISTRY
Volume 393, Issue 11, Pages 1357-1362

Publisher

WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2012-0135

Keywords

BioInformatics; carbohydrate; glycan; glycomics; glycoproteomics; mass spectrometry

Funding

  1. European Union [011952]
  2. Biotechnology and Biological Sciences Research Council (BBSRC) [BBF0083091]

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During the EUROCarbDB project our group developed the GlycanBuilder and GlycoWorkbench glycoinformatics tools. This short communication summarizes the capabilities of these two tools and updates which have been made since the original publications in 2007 and 2008. GlycanBuilder is a tool that allows for the fast and intuitive drawing of glycan structures; this tool can be used standalone, embedded in web pages and can also be integrated into other programs. GlycoWorkbench has been designed to semi-automatically annotate glycomics data. This tool can be used to annotate mass spectrometry (MS) and MS/MS spectra of free oligosaccharides, N and O-linked glycans, GAGs (glycosaminoglycans) and glycolipids, as well as MS spectra of glycoproteins.

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