Journal
BIOLOGICAL CHEMISTRY
Volume 392, Issue 1-2, Pages 13-19Publisher
WALTER DE GRUYTER & CO
DOI: 10.1515/BC.2011.013
Keywords
complex assembly; membrane biogenesis; protein evolution; protein folding; respiratory chain
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Funding
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) (Mexico) [105631, 121611]
- Deutsche Forschungsgemeinschaft (DFG) [FOR967, SFB 530]
- Human Frontiers Fellowship
- Direccion General de Asuntos del Personal Academico de la Universidad Nacional Autonoma de Mexico (DGAPA-UNAM) [IN-215810]
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Members of the YidC/Oxa1/Alb3 protein family facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria and the thylakoid membrane of plastids. All homologs share a conserved hydrophobic core region comprising five transmembrane domains. On the basis of phylogenetic analyses, six subgroups of the family can be distinguished which presumably arose from three independent gene duplications followed by functional specialization. During evolution of bacteria, mitochondria and chloroplasts, subgroup-specific regions were added to the core domain to facilitate the association with ribosomes or other components contributing to the substrate spectrum of YidC/Oxa1/Alb3 proteins.
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