4.2 Article

Brain content of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid and immune response in aggressive C57Bl/6J mice

Journal

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 130, Issue 10, Pages 954-956

Publisher

SPRINGER
DOI: 10.1023/A:1002853521450

Keywords

aggression; 5-hydroxytryptamine; brain structures; immune response

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Catabolism of 5-hydroxytryptamine in the midbrain raphe nuclei of aggressive C57B1/6J mice increased after 10 and 20 days of confrontations. Both catabolism and concentration of 5-hydroxytryptamine increased in the dopaminergic nuclei A11, A10, A9, and in the amigdala. The level of 5-hydroxyindoleacetic acid in the A9 and raphe nuclei decreased after 20 days of confrontations, which coincided with manifestation of the immune response.

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