Journal
MOLECULAR MEMBRANE BIOLOGY
Volume 17, Issue 4, Pages 189-200Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09687680010009646
Keywords
calcium pumps; x-ray structure; genetic diseases; phospholamban; sarcolipin
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This review examines the structure and function of the sarco(endo)plasmic reticulum calcium pump (SERCA1a) in the light of the recent publication of the 2.6 Angstrom resolution structure of this protein, and looks at the increasing awareness of the key role played by SERCAs in calcium signalling. The roles played by the calcium pump isoforms, SERCA1a/b, SERCA2a/b and SERCA3a/b/c in cellular function are discussed, and the modulation of SERCA activity by phospholamban, sarcolipin and other modulatory influences is examined. The recent discoveries of human SERCA mutations leading to disease states is reviewed, and the Insights into SERCA function using transgenic approaches are outlined.
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