Journal
BIOMATERIALS
Volume 21, Issue 19, Pages 1941-1946Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(00)00073-9
Keywords
biodegradable; poly(anhydride-ester); pH-dependent; in vitro degradation
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A biodegradable poly(anhydride-ester) was synthesized by melt condensation polymerization of the acetylated monomer to yield a novel polymeric prodrug. The polymer we have synthesized is composed of alkyl chains linked by ester bonds to aromatic moieties, specifically salicylic acid-the active component of aspirin. With the medicinal properties attributed to salicylic acid and the ease of metabolism, the incorporation of this compound into a polymer backbone yields a polymeric prodrug that may have potential in a variety of applications (i.e., inflammatory bowel disease). For these reasons, we have designed a synthetic scheme that yields the desired poly(anhydride-ester). The in vitro hydrolytic degradation of these polymers has been performed and results indicate that the polymer degradation rate is pH-dependent. (C) 2000 Elsevier Science Ltd. All rights reserved.
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