Journal
BIOLOGICAL CHEMISTRY
Volume 391, Issue 4, Pages 461-466Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2010.043
Keywords
alternative splicing; biomarker; kallikrein-related peptidase; prostate-specific antigen (PSA)
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PSA-RP2 is a variant transcript expressed from the PSA gene that is conserved in gorillas, chimpanzees and humans suggesting a particular relevance for this transcript in these primates. We demonstrated by qRT-PCR that PSA-RP2 is upregulated in prostate cancer compared with benign prostatic hyperplasia tissues. The PSA-RP2 protein was not detected in seminal fluid and was cytoplasmically localised but not secreted from LNCaP or transfected PC3 prostate cells, despite secretion from transfected Cos-7 and HEK293 kidney cell lines. PSA-RP2-transfected PC3 cells showed slightly decreased proliferation and increased migration towards PC3-conditioned medium that could suggest a functional role in prostate cancer.
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