Journal
BIOLOGICAL CHEMISTRY
Volume 390, Issue 7, Pages 647-656Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2009.071
Keywords
carbohydrate-binding protein; glycolipid; glycoprotein; neoglycolipid; oligosaccharide; polysaccharide
Categories
Funding
- U.K. Medical Research Council
- U.K. Research Councils Basic Technology Grant [GR/S79268]
- NCI Alliance of Glycobiologists for Detection of Cancer and Cancer Risk [U01 CA128416]
- Welcome Trust
- Fundacao para a Ciencia e Tecnologia, Portugal [SFRH/BPD/26515/2006]
- MRC [G0600512, MC_U117533887] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/S79268/02] Funding Source: researchfish
- Medical Research Council [G0600512, MC_U117533887] Funding Source: researchfish
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/26515/2006] Funding Source: FCT
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Carbohydrate chains of glycoproteins, glycolipids, proteoglycans, and polysaccharides mediate processes of biological and medical importance through their interactions with complementary proteins. The unraveling of these interactions is therefore a priority in biomedical sciences. Carbohydrate microarray technology is a new development at the frontier of glycomics that is revolutionizing the study of carbohydrate-protein interactions and the elucidation of their specificities in endogenous biological processes, microbe-host interactions, and immune defense mechanisms. In this review, we briefly refer to the principles of numerous platforms since the introduction of carbohydrate microarrays in 2002, and we highlight platforms that are beyond proof-of-concept and have provided new biological information.
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