Journal
BRITISH JOURNAL OF CANCER
Volume 83, Issue 7, Pages 870-873Publisher
NATURE PUBLISHING GROUP
DOI: 10.1054/bjoc.2000.1395
Keywords
fascin; breast cancer; motility; hormone receptor oestrogen; progesterone
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Funding
- NIGMS NIH HHS [R01GM52112] Funding Source: Medline
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Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers; oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P < 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour. (C) 2000 cancer Research campaign.
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