Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 1, Issue 1, Pages 22-30Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35036044
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A strikingly large number of the proteins involved in DNA metabolism adopt a toroidal - or ring-shaped - quaternary structure, even though they have completely unrelated functions. Given that these proteins all use DNA as a substrate, their convergence to one shape is probably not a coincidence. Ring-forming proteins may have been selected during evolution for advantages conferred by the toroidal shape on their interactions with DNA.
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