Journal
JOURNAL OF CHEMICAL NEUROANATOMY
Volume 20, Issue 1, Pages 49-59Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0891-0618(00)00067-3
Keywords
Alzheimer's disease; human brain; myeloarchitectonics; neuropathology; neuron number; stereology; striatum
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Celloidin mounting (embedding without infiltration) of the human central nervous system (CNS) proved to be superior to gelatin embedding for the production of serial sections ranging in thickness from 220 to 500 mum. After gallocyanin-staining, a comprehensive neuroanatomical as well as neuropathological survey of the human brain is possible, including diagnosis of Alzheimer's disease. Details of a fractionator analysis of the total striatal neuron number are described and the possible quantitative analysis of parallel immunohistochemically stained sections is discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
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